Alumnus Since
2022
First position after graduation
PhD Student in Biostatistics, University of Toronto
Thesis/Project
Variance as a predictor for survival outcomes
Graduate Student Research Assistant (November 2021 to August 2022), co-advised with Mike Elliott.
Papers (partial)
1. Prediction-based Inference in Electronic Health Record (EHR)-linked Biobanks with Clinically Informative Outcomes.
Xingran Chen,
Cheng-Han Yang,
Zhenke Wu,
Bhramar Mukherjee (submitted)
►
[paper link]
2. A joint modeling approach to study the association between subject-level longitudinal marker variabilities and repeated outcomes.
Irena Chen,
Zhenke Wu,
Sioban D Harlow,
Carrie A Karvonen-Gutierrez,
Michelle M Hood,
Michael R Elliott (2025)
► Journal of Applied Statistics
[paper link]
3. Beyond Average Value Function in Precision Medicine: Maximum Probability-Driven Reinforcement Learning for Survival Analysis.
Jianqi Feng,
Wei Zhao,
Zhenke Wu,
Chengchun Shi,
Xiaodong Yan (2025)
► NeurIPS
4. A Unified Framework for Inference with General Missingness Patterns and Machine Learning Imputation.
Xingran Chen,
Tyler McCormick,
Bhramar Mukherjee,
Zhenke Wu (submitted)
►
[paper link]
5. PyCFRL: A Python library for counterfactually fair offline reinforcement learning via sequential data preprocessing.
Jianhan Zhang,
Jitao Wang,
Chengchun Shi,
John Piette,
Donglin Zeng,
Zhenke Wu (submitted)
►
[paper link]
[code]
[pdf]
[poster]
[supplement]
6. Generating Synthetic Electronic Health Record (EHR) Data: A Methodological Scoping Review with Benchmarking on Phenotype Data and Open-Source Software.
Xingran Chen,
Zhenke Wu,
Xu Shi,
Hyunghoon Cho,
Bhramar Mukherjee (2025)
► Journal of the American Medical Informatics Association
[paper link]
[code]
[doi]
7. Testing Stationarity and Change Point Detection in Reinforcement Learning.
Mengbing Li,
Chengchun Shi,
Zhenke Wu,
Piotr Fryzlewicz (2025)
► Annals of Statistics
[paper link]
[code]
8. Counterfactually Fair Reinforcement Learning via Sequential Data Preprocessing.
Jitao Wang,
Chengchun Shi,
John Piette,
Joshua Loftus,
Donglin Zeng,
Zhenke Wu (submitted)
►
[paper link]
[poster]
9. Multivariate Dynamic Mediation Analysis under a Reinforcement Learning Framework.
Lan Luo*,
Chengchun Shi*,
Jitao Wang*,
Zhenke Wu,
Lexin Li (2025)
► Annals of Statistics
[paper link]
[doi]
10. Variance as a predictor of health outcomes:using subject-level trajectories and variability of sex hormones to predict body fat changes in peri- and post-menopausal women.
Irena Chen,
Zhenke Wu,
Sioban D Harlow,
Carrie A Karvonen-Gutierrez,
Michelle M Hood,
Michael R Elliott (2024)
► Annals of Applied Statistics
[doi]
[pdf]
[supplement]
11. Tree-informed Bayesian multi-source domain adaptation: cross-population probabilistic cause-of-death assignment using verbal autopsy.
Zhenke Wu,
Zehang Richard Li,
Irena Chen,
Mengbing Li (2024)
► Biostatistics
[paper link]
[code]
[supplement]
[slides]
12. Etiology of acute lower respiratory illness hospitalizations among infants in four countries.
John Kubale*,
Stephanie Kujawski*,
Irena Chen,
Zhenke Wu,
Ilham Abu Khader,
Iris Hasibra,
Brett Whitaker,
Lionel Gresh,
Artan Simaku,
Eric A.F. Simões,
Mahmoud Al-Gazo,
Shannon Rogers,
Susan I. Gerber,
Angel Balmaseda,
Veronica L. Tallo,
Tareq M. Al-Sanouri,
Rachael Porter,
Silvia Bino,
Eduardo Azziz-Baumgartner,
Meredith McMorrow,
Danielle Hunt,
Mark Thompson,
Holly M. Biggs,
Aubree Gordon (2023)
► Open Forum Infectious Diseases
[doi]
13. Bayesian Nested Latent Class Models for Cause-of-Death Assignment using Verbal Autopsies Across Multiple Domains.
Richard Zehang Li,
Zhenke Wu,
Irena Chen,
Samuel Clark (2024)
► Annals of Applied Statistics
[code]
[doi]
14. An Automatically-Adaptive Digital Health Intervention to Decrease Opioid-Related Risk While Conserving Counselor Time: Analysis of Treatment Decisions Based on Artificial Intelligence and Patient-Reported Risk Measures.
John D Piette,
Laura Thomas,
Sean Newman,
Nicolle Marinec,
Joel Krauss,
Jenny Chen,
Zhenke Wu,
Amy SB Bohnert (2023)
► Journal of Medical Internet Research
15. A Reinforcement Learning Framework for Dynamic Mediation Analysis.
Lin Ge,
Jitao Wang,
Chengchun Shi,
Zhenke Wu,
Rui Song (2023)
► ICML
[paper link]
[code]
16. A Robust Test for the Stationarity Assumption in Sequential Decision Making.
Jitao Wang,
Chengchun Shi,
Zhenke Wu (2023)
► ICML
[paper link]
[code]
[pdf]
17. Doubly Inhomogeneous Reinforcement Learning.
Liyuan Hu*,
Mengbing Li*,
Chengchun Shi,
Zhenke Wu,
Piotr Fryzlewicz (submitted)
►
[paper link]
[code]
18. baker: An R package for Nested Partially-Latent Class Models.
Irena Chen,
Qiyuan Shi,
Scott Zeger,
Zhenke Wu (submitted)
►
[paper link]
[code]
[pdf]
19. A Hierarchical Integrative Group LASSO (HiGLASSO) Framework for Analyzing Environmental Mixtures.
Jonathan Boss,
Yin-Hsiu Chen,
Naveen N. Narisetty,
Zhenke Wu,
Kelly K. Ferguson,
Thomas F. McElrath,
John D. Meeker,
Bhramar Mukherjee (2021)
► Environmetrics
[paper link]
20. Probabilistic Cause-of-disease Assignment using Case-control Diagnostic Tests: A Hierarchcial Bayesian Latent Variable Regression Approach.
Zhenke Wu,
Irena Chen (2020)
► Statistics in Medicine
[paper link]
[code]
[doi]
[poster]
[supplement]
[slides]
21. Characterization of clinical progression of COVID-19 patients in Shenzhen, China.
Qifang Bi,
Chengcheng Hong,
Juan Meng,
Zhenke Wu,
Pengzheng Zhou,
Chenfei Ye,
Binbin Sun,
Lauren Kucirka,
Andrew S Azman,
Tong Wang,
Jiancong Chen,
Zhaoqin Wang,
Lei Liu,
Justin Lessler,
Jessie Edwards,
Ting Ma,
Guoliang Zhang (2020)
► medRxiv
[paper link]