congrats to students
02 May 2022 by Zhenke Wu

Congratulations to Tsung-Hung Yao (co-advisor: Veera Baladandayuthapani) for receiving a competitive travel award to 2022 International Society of Bayesian Analysis (ISBA), Montreal. This is based on his work “Probabilistic Learning of Treatment Trees in Cancer”.

Congratulations to Hera Shi (co-advisor: Walter Dempsey) for receiving a competitive Junior Researcher Travel Grant to attend 2022 American Causal Inference Conference (ACIC) at Berkeley, CA. This is based on her work “Assessing Time-Varying Causal Effect Moderation in the Presence of Cluster-Level Treatment Effect Heterogeneity”.

baker on CRAN!
02 Feb 2022 by Zhenke Wu

baker has a first public release (v1.0.0) at CRAN! Discussion related to version 1.0.0 can be submitted to here; [vignette] [source code].

The definitive reference for baker R package can be found here.

This vignette describes and illustrates the functionality of the baker R package. The package provides a suite of nested partially-latent class models (NPLCM) for multivariate binary responses that are observed under a case-control design. The baker package allows researchers to flexibly estimate population- and individual-level class distributions that may also depend on additional explanatory covariates.

Functions in baker implement recent methodological developments in our group (here, here, and here). Estimation is accomplished by calling a cross-platform automatic Bayesian inference software JAGS through a wrapper R function that parses model specifications and data inputs. The baker package provides many useful features, including data ingestion, exploratory data analyses, model diagnostics, extensive plotting and visualization options, catalyzing vital communications between practitioners and domain scientists. Package features and workflows are illustrated using simulated and real data sets.

The focus of this document is on guiding a new user to utilize some useful functions in baker for simulation studies and data analyses, aided by other powerful R packages. We refer readers of this document to the accompanying main software paper for more details about the software design considerations and review of model formulations. Since baker’s first appearance on Github, the authors have not been able to track other recent substantive publications that have used this package; we hope the main software paper and this vignette serve as the definitive reference for future scientific studies that find the baker package useful.

Newly funded data science project
28 May 2021 by Zhenke Wu

An exciting new collaboration is supported by 2021 Propelling Original Data Science (PODS) grant from Michigan Institute for Data Science (MIDAS). The project title is “Structured Latent Variable Methods for High-Dimensional Electronic Health Records and Administrative Claims Data”. The faculty investigators are Zhenke Wu (PI; Biostatistics, Public Health), Jordan Schaefer (Co-I; Hematology, Internal Medicine), and Andrew Ryan (Co-I; Health Management and Policy, Public Health). The primary data source will be based on UnitedHealthcare OptumInsight claims data via Data and Methods Hub (DMH) at UM Institute for Healthcare Policy and Innovation (IHPI).

Congrats to Irena and Hera
01 Sep 2020 by Zhenke Wu

Huge congrats to Irena and Hera for passing their PhD qualifying exams!!

Congrats to Mengbing and Irena
15 Nov 2019 by Zhenke Wu

Huge congrats to Mengbing for winning “Best Doctoral Qualifying Exam Award”.

Another huge congrats to Irena for winning a poster award today in the 2019 MIDAS Annual Symposium in the category of “Most Likely to Make an Impact in the Field” for her poster “Regression Analysis for Probabilistic Cause-of-disease Assignment using Case-control Diagnostic Tests: A Hierarchical Bayesian Approach”!

Way to go!!

PERCH Main Results out in The Lancet
28 Jun 2019 by Zhenke Wu

The Main PERCH paper appeared in The Lancet today. We developed novel integrative Bayesian methods here, here, here, and more recently, here. Also check out the open-source R pacakge baker.

The visualization of PERCH results can be found here.

A press release is here.

Congrats to Tim and Mengbing
13 Jun 2019 by Zhenke Wu

Huge congrats to Tim for having successfully defended his thesis on sequential randomized trials motivated by mental health and online education problems!

Another huge congrats to Mengbing for finishing her MS degree in biostatistics!

Previliged to have worked with you together in the past two years. Way to go!

U of Michigan Precision Health Investigator Award
24 Oct 2018 by Zhenke Wu

Our two-year project “Bayesian Hierarchical Models for Using Mobile Technology to Individualize Care in Mental Health” is funded by Precision Health at University of Michgian for developing analytical capacities and software tools suitable for mobile data streams. It is motivated by an ongoing multi-institution study of depression among first year medical interns.

Michigan Student Symposium for Interdisciplinary Statistical Sciences
04 Apr 2018 by Zhenke Wu

Tim Necamp won the Best Speed Oral Presentation at MSSISS 2018 for his work with Intern Health Study. His poster is entitled Predicting mood using multivariate mobile sensor data streams for medical interns. I also had great fun delivering junior faculty keynote talk titled Bayesian Hierarchical Methods to Power Disease Discovery and Improve Clinical Decisions. Thanks for the fantastic student organizing committee and faculty advisory committee from Biostat, EECS, IOE, Stat and Survey Methodology for showcasing the diverse statistical/data science work at Michigan.

Electronic Health Records Projects
08 Aug 2017 by Zhenke Wu

For six weeks, 44 undergraduate students from across the country met at Ann Arbor to wrestle with big data. The hands-on projects, in addition to lectures about statistics, informatics and professional development, are part of their training at 2017 Big Data Summer Institute hosted by our department. Among them, eleven students learned and applied methods to analyzing the Electronic Health Records (EHR) data. In four groups, they created their own data sets from Michigan Genomics Initiative that contains genomic information, longitudinal diagnoses, procedures and lab measurements and more to investigate heart failure, phenomewide association for lab values, Type 2 Diabetes and infectious diseases. It was great pleasure working with you!

Our team receives Data Science Challenge Initiative award in mobile health analytics
09 Apr 2017 by Zhenke Wu

Frequent interactions of individuals with mobile devices have opened new doors to behavioral and mental health research. The real-time individual-level data streams unleashed by mobile technologies have greatly improved our potential to understanding behaviors and improving health. For example, mobile technologies can capture the opportunistic windows during the day for maintaining healthy behaviors, push actionable suggestion messages, and help individuals develop and maintain long-term changes beneficial to their health. For the current project, we hope the privacy-protected data will ultimately refine our understanding of how life stress leads to depression and hence transform our ability to prevent and treat depression.

See the project award notice for more information about our project titled Identifying Real-Time Data Predictors of Stress and Depression Using Mobile Technology.

Statisticians Impacting Global Public Health
24 Feb 2017 by Zhenke Wu

There are many statistical innovations going on in Global Health. Here is the newsletter pointing to some ongoing research activities and consulting services available at Global Pubic Health, Michigan.

Teaching a special topics course about graphical models
21 Sep 2016 by Zhenke Wu

I am now teaching a PhD-level special topics course: BIOSTAT830 Statistical and Computational Methods for Learning Through Graphical Models, which will cover representation, inference, learning and causality demonstrated by case studies on real problems. Feel free to get what you need or comment on the course webpage.

Will join U of Michigan Biostat and MIDAS
05 Jul 2016 by Zhenke Wu

I will join Department of Biostatistics at Univeristy of Michigan as Assistant Professor, with joint appointment at Michigan Institute for Data Science (MIDAS), starting from September 1st, 2016.

Visualization for Individualized Health
11 May 2016 by Zhenke Wu

As part of their final project for Data Visualization for Individualized Health, Audrey Garman, Bengucan Gunen, Ruthe Huang, and Marcus Spearman, majored in public health studies, have built an excellent childhood pneumonia prediction visualization tool using Shiny. See the Hopkins inHealth and the HUB stories.

Welcome!
06 Oct 2015 by Zhenke Wu

Theory and experiment, the pillars of 19-20th century science, have been joined by computation and big data in the 21st.

I am always looking for people who take a quantitative approach to studying public health, biology and biomedicine. Particular emphasis is placed on scalable Bayesian (graphical) modeling, latent variables, causal inference and especially their intersection. If you think you may be interested, please get in touch.

I’d be happy to answer questions on research and software!